(Record no. 137187)

MARC details
000 -LEADER
fixed length control field 03227nam a22002897i 4500
001 - CONTROL NUMBER
control field 016331430
003 - CONTROL NUMBER IDENTIFIER
control field IQ-KoUCL
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20150902092805.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr |||||||||||
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100922s2012 xxk obm 000 0 eng
040 ## - CATALOGING SOURCE
Original cataloging agency dlc
Language of cataloging dlc
Description conventions dlc
Transcribing agency Uk
Modifying agency Uk
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616.9944907
Edition number 23
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name jo armes
Relator term author.
245 13 - TITLE STATEMENT
Title fatigue in cancer
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE
Title fatigue in cancer
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.)--St George's, University of London, 2012.
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references.
520 3# - SUMMARY, ETC.
Summary, etc Background: 30-40% of women successfully treated for breast cancer experience chronic fatigue for up to five years after the end of therapy. They experience a number of associated problems including reduced quality of life, lower mood and concentration difficulties. The causes of these problems and the underlying biological pathogenesis of these symptoms are unclear. The primary objective of this research was to identify whether there were differences in objective activity, cognitive function and inflammatory cytokines between fatigued and non-fatigued women post-treatment. Methods: This was a cross-sectional observational study. Women were recruited from a nurse-led follow-up clinic at St George's hospital over a two-and-a-half-year period. These women were categorised on the basis of a semi-structured interview as to whether they met the criteria to be a case of cancer-related fatigue syndrome (CRFS) or acted as a control. All participants completed a set of questionnaires, activity recording, cognitive testing and had blood taken for analysis. Samples were sent to a commercial company for analyte panel testing (88 markers) and were also analysed using proteomic techniques (including mass spectrometry) to identify any differences in plasma proteins between groups. Results: 114 women were recruited; 45 cases and 69 controls. A between group analysis demonstrated statistically significant differences in sleep quality (p=0.02) and daytime activity (p=0.03) on activity recording, and slower processing speed (p=0.009) and impaired verbal memory (p=0.03) on cognitive testing. Blood analysis demonstrated statistically significant differences (p<0.03) with raised inflammatory cytokines on commercial testing (interleukin 18, vascular endothelial growth factor and macrophage inflammatory protein 1) and increased non-specific inflammatory markers on an exploratory proteomic analysis (serum amyloid A and collectin). Conclusions: Statistically significant differences in subjective symptoms, e.g. difficulty concentrating, and linked objective data, e.g. reduced cognitive processing speed, were identified. These differences were associated with evidence of an underlying prolonged inflammatory response (indicated by raised cytokine levels) in the CRFS group. Future work should examine these observed differences prospectively before, during and after treatment.
600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME
Personal name jo armes
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element St. George's Hospital (London, England).
Subordinate unit Medical School,
Relator term degree granting institution.
903 ## - LOCAL DATA ELEMENT C, LDC (RLIN)
a 568717
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Books
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection code Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
            Koya University Central Library Koya University Central Library Book Cart 02/09/2015   616.994 cut 7288 0000044935 02/09/2015 02/09/2015 Books
            Koya University Central Library Koya University Central Library Book Cart 02/09/2015   616.994 cut 7288 0000044936 02/09/2015 02/09/2015 Books