(Record no. 137187)
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000 -LEADER | |
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fixed length control field | 03227nam a22002897i 4500 |
001 - CONTROL NUMBER | |
control field | 016331430 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | IQ-KoUCL |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20150902092805.0 |
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION | |
fixed length control field | m d |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr ||||||||||| |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 100922s2012 xxk obm 000 0 eng |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | dlc |
Language of cataloging | dlc |
Description conventions | dlc |
Transcribing agency | Uk |
Modifying agency | Uk |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 616.9944907 |
Edition number | 23 |
100 1# - MAIN ENTRY--PERSONAL NAME | |
Personal name | jo armes |
Relator term | author. |
245 13 - TITLE STATEMENT | |
Title | fatigue in cancer |
300 ## - PHYSICAL DESCRIPTION | |
Extent | 1 online resource |
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
Title | fatigue in cancer |
502 ## - DISSERTATION NOTE | |
Dissertation note | Thesis (Ph.D.)--St George's, University of London, 2012. |
504 ## - BIBLIOGRAPHY, ETC. NOTE | |
Bibliography, etc | Includes bibliographical references. |
520 3# - SUMMARY, ETC. | |
Summary, etc | Background: 30-40% of women successfully treated for breast cancer experience chronic fatigue for up to five years after the end of therapy. They experience a number of associated problems including reduced quality of life, lower mood and concentration difficulties. The causes of these problems and the underlying biological pathogenesis of these symptoms are unclear. The primary objective of this research was to identify whether there were differences in objective activity, cognitive function and inflammatory cytokines between fatigued and non-fatigued women post-treatment. Methods: This was a cross-sectional observational study. Women were recruited from a nurse-led follow-up clinic at St George's hospital over a two-and-a-half-year period. These women were categorised on the basis of a semi-structured interview as to whether they met the criteria to be a case of cancer-related fatigue syndrome (CRFS) or acted as a control. All participants completed a set of questionnaires, activity recording, cognitive testing and had blood taken for analysis. Samples were sent to a commercial company for analyte panel testing (88 markers) and were also analysed using proteomic techniques (including mass spectrometry) to identify any differences in plasma proteins between groups. Results: 114 women were recruited; 45 cases and 69 controls. A between group analysis demonstrated statistically significant differences in sleep quality (p=0.02) and daytime activity (p=0.03) on activity recording, and slower processing speed (p=0.009) and impaired verbal memory (p=0.03) on cognitive testing. Blood analysis demonstrated statistically significant differences (p<0.03) with raised inflammatory cytokines on commercial testing (interleukin 18, vascular endothelial growth factor and macrophage inflammatory protein 1) and increased non-specific inflammatory markers on an exploratory proteomic analysis (serum amyloid A and collectin). Conclusions: Statistically significant differences in subjective symptoms, e.g. difficulty concentrating, and linked objective data, e.g. reduced cognitive processing speed, were identified. These differences were associated with evidence of an underlying prolonged inflammatory response (indicated by raised cytokine levels) in the CRFS group. Future work should examine these observed differences prospectively before, during and after treatment. |
600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
Personal name | jo armes |
710 2# - ADDED ENTRY--CORPORATE NAME | |
Corporate name or jurisdiction name as entry element | St. George's Hospital (London, England). |
Subordinate unit | Medical School, |
Relator term | degree granting institution. |
903 ## - LOCAL DATA ELEMENT C, LDC (RLIN) | |
a | 568717 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Books |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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Koya University Central Library | Koya University Central Library | Book Cart | 02/09/2015 | 616.994 cut 7288 | 0000044935 | 02/09/2015 | 02/09/2015 | Books | |||||||
Koya University Central Library | Koya University Central Library | Book Cart | 02/09/2015 | 616.994 cut 7288 | 0000044936 | 02/09/2015 | 02/09/2015 | Books |